An organocatalyzed facile and rapid access to alpha-hydroxy and alpha-amino phosphonates under conventional/ultrasound technique

作者：Shinde Pravin V; Kategaonkar Amol H; Shingate Bapurao B; Shingare Murlidhar S^*

来源：Tetrahedron Letters, 2011, 52(22): 2889-2892.

DOI：10.1016/j.tetlet.2011.03.138

• alpha-Hydroxy phosphonates
• alpha-Amino phosphonates
• Ultrasonication
• Camphor sulfonic acid
• Solvent-free reaction

In the present work, successful implementation of ultrasound irradiation for the rapid synthesis of alpha-hydroxy and alpha-amino phosphonates under solvent-free conditions is demonstrated. Use of a novel catalyst (i.e., camphor sulfonic acid) in combination with ultrasound technique is reported for the first time. Comparative study for the synthesis of alpha-hydroxy and alpha-amino phosphonates using conventional as well as ultrasonication method is discussed.

• 出版日期2011-6-1