A convenient synthesis of gimeracil

作者:Li, Xiao-lin; Zhu, Hao-ting; Zhan, Li; Liu, Ting; Cheng, Guang; Liu, Ning; Yu, Shan-bao; Li, Hui; Luo, Yu*; Yang, Fan; Tang, Jie
来源:Journal of Chemical Research, 2018, 42(1): 33-34.
DOI:10.3184/174751918X15166150010920

摘要

A practical three-step synthetic approach to gimeracil in a 68% overall yield is described, using 2,4-dimethoxypyridine as the starting material with 3,5-dichloro-2,4-dimethoxypyridine and 3,5-dichloro-2,4-dihydroxypyridine as intermediates. The advantages of this procedure include short reaction steps, simple operation and good yield.