Molecular Size of Collagen Peptide Reverses the Permeability of Caco-2 Cells

作者：Shimizu Kazuo^*; Sato Mikako; Zhang Youzuo; Kouguchi Tomomi; Takahata Yoshihisa; Morimatsu Fumiki; Shimizu Makoto

来源：Bioscience Biotechnology and Biochemistry, 2010, 74(5): 1123-1125.

DOI：10.1271/bbb.100015

• fish collagen peptide
• paracellular pathway
• tight junction
• permeability
• Caco-2 cells

Intestinal permeability to size-classified fish collagen peptides (FCPs) was examined using Caco-2 monolayers. Minimum-sized FCPs were most efficiently transported across the Caco-2 monolayers. Permeability depended on peptide size. It was independent of the H+-coupled peptide transport system but was associated with tight junction permeability, suggesting that the paracellular pathway is responsible for transepithelial transport of collagen peptides.

• 出版日期2010-5