Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy

作者：Sobko Tanja^*; Schiott Jessica; Ehlin Anna; Lundberg Jon; Montgomery Scott; Norman Mikael

来源：Paediatric and Perinatal Epidemiology, 2010, 24(1): 88-92.

DOI：10.1111/j.1365-3016.2009.01080.x

• neonatal infection
• hygiene hypothesis
• antibiotics
• eczema
• asthma
• hay fever

P>Sobko T, Schiott J, Ehlin A, Lundberg J, Montgomery S, Norman M. Neonatal sepsis, antibiotic therapy and later risk of asthma and allergy. Paediatric and Perinatal Epidemiology 2010; 24: 88-92.
Neonatal sepsis and early antibiotic therapy affect bacterial colonisation and immune activation after birth. This could have implications for later risk of allergy and asthma. Using a validated questionnaire (International Study of Asthma and Allergies in Children, ISAAC), we screened for asthma and allergy in three cohorts (total n = 834; median age 12, range 7-23 years) with different perinatal exposures as regards infection and antibiotics.
Asthma, but not hay fever, was more prevalent after neonatal sepsis with adjusted odds ratio (OR) 1.63 [95% confidence interval (CI) 1.04, 2.56] and early antibiotic therapy (OR 1.48 [0.93, 2.35]) as compared with a control group. There was a trend towards increased atopic eczema after neonatal sepsis (OR = 1.39 [CI = 0.98, 1.98]). We conclude that neonatal sepsis is associated with an increased risk for later development of asthma. Early antibiotic exposure may contribute to this association.

• 出版日期2010-1