Endothelial Glycocalyx Damage Is Associated with Leptospirosis Acute Kidney Injury

作者：Liborio Alexandre Braga^*; Munoz Braz Marcelo Boecker; Seguro Antonio Carlos; Meneses Gdayllon C; de Oliveira Neves Fernanda Macedo; Pedrosa Danielle Carvalho; de Goes Cavalcanti Luciano Pamplona; Costa Martins Alice Maria; Daher Elizabeth de Francesco

来源：The American Journal of Tropical Medicine and Hygiene, 2015, 92(3): 611-616.

DOI：10.4269/ajtmh.14-0232

Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 +/- 31.7 versus 234.9 +/- 24.4 mg/L, P < 0.001) and syndecan-1 (73.7 +/- 15.9 versus 21.2 +/- 7.9 ng/mL, P < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 +/- 45.4 versus 41.5 +/- 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 +/- 70.4 versus 434.9 +/- 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage.

• 出版日期2015-3