Adsorption of DNA Nitrogenous Bases on Nanodiamond Particles: Theory and Experiment

作者：Laptinskiy K A^*; Vervald E N; Bokarev A N; Burikov S A; Torelli M D; Shenderova O A; Plastun I L; Dolenko T A

来源：Journal of Physical Chemistry C, 2018, 122(20): 11066-11075.

DOI：10.1021/acs.jpcc.7b12618

Efficiency of adsorption of nucleic acid nitrogenous bases (NBs) on carboxylated detonation nanodiamond (DND-COOH) particles in aqueous media at pH = 7.4-7.6 and pH = 13.4 was investigated using Raman spectroscopy and infrared (IR) absorption spectroscopy. A significant difference in the adsorption activity of NDs toward four different individual NBs, guanine, adenine, cytosine, and thymine, had been observed. The highest adsorption activity on DND-COOH was observed for cytosine and, in descending order, for adenine and thymine. At the same time, adsorption activities of the adenine-thymine and guanine-cytosine complementary pairs on nanodiamonds (NDs) were similar. Analysis of the hydrogen bond parameters in the adsorption of complementary pair adenine-thymine on the ND surface had been done using the density functional theory-based molecular modeling. The theoretical calculations are consistent with the experimental results.

• 出版日期2018-5-24