Anti-apoptotic effects of recombinant human granulocyte colony-stimulating factor in focal cerebral ischemic rats

作者：Yuan, Xia; Zhang, Shiming^*; Dong, Wanli; Fang, Qi

来源：Neural Regeneration Research, 2011, 6(11): 839-844.

DOI：10.3969/j.issn.1673-5374.2011.11.008

• recombinant human granulocyte colony-stimulating factor
• cerebral ischemia/reperfusion injury
• anti-apoptosis
• neural regeneration

The neuroprotective effects of granulocyte colony-stimulating factor in cerebral ischemia/reperfusion injury are currently contentious. The present study examined the effects of subcutaneous injection of recombinant human granulocyte colony-stimulating factor (50 mu g/kg) over 5 days in a model of cerebral ischemia/reperfusion with intraluminal filament occlusion in rats. The results indicated that recombinant human granulocyte colony-stimulating factor reduced brain infarct volume following cerebral ischemia/reperfusion injury in rats, down-regulated the expression of caspase-3 mRNA (a key protease for apoptosis in the cerebral ischemia zone), lowered the rate of neuronal apoptosis in the cerebral ischemia zone, and notably ameliorated neurological function. These results indicate that recombinant human granulocyte colony-stimulating factor has anti-apoptotic effects on neurons following focal cerebral ischemia/reperfusion injury, and exerts neuroprotective effects.

• 出版日期2011-4-15
• 单位苏州大学