Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa

作者：Bakkiyaraj Dhamodharan; Sivasankar Chandran; Pandian Shunmugiah Karutha^*

来源：Indian Journal of Microbiology, 2013, 53(1): 111-113.

DOI：10.1007/s12088-012-0342-3

• Quorum sensing
• Pseudomonas aeruginosa
• Coral associated bacteria
• Biofilm
• Anti-QS
• Quorum sensing inhibitor

Infections of Pseudomonas aeruginosa are of great concern because of its increasing resistance towards conventional antibiotics. Quorum sensing system of P. aeruginosa acts as a global regulator of almost all the virulence factors and majorly its biofilm formation. In the present study, quenching of QS system of P. aeruginosa has been explained with bioactives from bacteria associated with the coral Acropora digitifera. Isolated bioactives inhibited the expression of various virulence traits of P. aeruginosa like biofilm formation, and the production of extracellular enzymes like protease and elastase. This study also emphasises the potential of coral associated bacteria in producing bioactive agents with anti-pathogenic properties.

• 出版日期2013-3