A highly diastereoselective oxa-Pictet-Spengler approach to (+)-astropaquinone B and (+)-astropaquinone C and the formation of astropaquinone B dimer

作者：Fernandes Rodney A^*; Mulay Sandip V

来源：Tetrahedron: Asymmetry , 2013, 24(20): 1281-1285.

DOI：10.1016/j.tetasy.2013.09.001

A concise and highly diastereoselective synthesis of (+)-astropaquinone B and (+)-astropaquinone C is reported. The synthetic strategy is based on an efficient combination of Dotz benzannulation using a chiral alkyne to construct the naphthalene unit and a highly diastereoselective oxa-Pictet-Spengler reaction to install the trans-configured pyran ring as the key steps.

• 出版日期2013-10-31