SNPs in CAST Are Associated With Parkinson Disease: A Confirmation Study

作者：Allen Andrew S^*; Satten Glen A

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2010, 153B(4): 973-979.

DOI：10.1002/ajmg.b.31061

• Parkinson disease
• calpastatin
• SNP association

Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (P= 0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.

• 出版日期2010-6