Age differences in presentation, diagnosis pathway and management of colorectal cancer

作者：Esteva Magdalena^*; Ruiz Amador; Ramos Maria; Casamitjana Monserrat; Sanchez Calavera Maria A; Gonzalez Lujan Luis; Pita Fernandez Salvador; Leiva Alfonso; Pertega Diaz Sonia; Costa Alcaraz Ana M; Macia Francesc; Espi Alejandro; Segura Josep M; Lafita Sergio; Novella Maria T; Yus Carmen; Olivan Barbara; Cabeza Elena; Seoane Pillado Teresa; Lopez Calvino Beatriz; Llobera Joan

来源：Cancer Epidemiology, 2014, 38(4): 346-353.

DOI：10.1016/j.canep.2014.05.002

• Colorectal cancer
• Elderly
• Early diagnosis
• Treatment
• Primary health care
• Secondary care
• Health services accessibility
• Quality of health care

Background: The gap in survival between older and younger European cancer patients is getting wider. It is possible that cancer in the elderly is being managed or treated differently than in their younger counterparts. This study aims to explore age disparities with respect to the clinical characteristics of the tumour, diagnostic pathway and treatment of colorectal cancer patients. %26lt;br%26gt;Methods: We conducted a multicenter cross sectional study in 5 Spanish regions. Consecutive incident cases of CRC were identified from pathology services. Measurements: From patient interviews, hospital and primary care clinical records, we collected data on symptoms, stage, doctors investigations, time duration to diagnosis/treatment, quality of care and treatment. %26lt;br%26gt;Results: 777 symptomatic cases, 154 were older than 80 years. Stage was similar by age group. General symptoms were more frequent in the eldest and abdominal symptoms in the youngest. No differences were found regarding perception of symptom seriousness and symptom disclosure between age groups as no longer duration to diagnosis or treatment was observed in the oldest groups. In primary care, only ultrasound is more frequently ordered in those %26lt;65 years. Those %26gt;80 years had a significantly higher proportion of iron testing and abdominal XR requested in hospital. We observed a high resection rate independently of age but less adjuvant chemotherapy in Stage III colon cancer, and of radiotherapy in stage II and III rectal cancer as age increases. %26lt;br%26gt;Conclusion: There are no relevant age disparities in the CRC diagnosis process with similar stage, duration to diagnosis, investigations and surgery. However, further improvements have to be made with respect to adjuvant therapy.

• 出版日期2014-8