Assessment of Serum Copper State after Gastrectomy with Roux-en-Y Reconstruction for Gastric Cancer

作者：Nakagawa Masatoshi^*; Kojima Kazuyuki; Lnokuchi Mikito; Kato Keiji; Sugita Hirofumi; Otsuki Sho; Higuchi Kyoko; Kobayashi Kenta; Sugihara Kenichi

来源：Digestive Surgery, 2015, 32(4): 301-305.

DOI：10.1159/000431186

• Copper
• Roux-en-Y reconstruction
• Gastric cancer
• Gastrectomy

Background: Some recent reports have noted that copper deficiency can occur in obese patients who have undergone bariatric surgery, such as Roux-en-Y (RY) gastric bypass or biliopancreatic diversion, or in patients who receive enteral nutrition through a jejunostomy. No reports appear to have assessed the serum copper state of patients following gastrectomy with RY reconstruction for gastric cancer. Methods: A cross-sectional study was conducted from June 2013 to December 2014. Serum copper levels (SCLs) in 242 out-clinic patients who underwent curative gastrectomy were obtained. Patients were classified into an RY group (n = 208) and a non-RY group (n = 34). Results: Hypocupremia was identified in 3 patients in the RY group (1.4%), and 2 patients in the non-RY group (5.9%; p = 0.146), but none experienced any symptoms caused by hypocupremia. No significant difference in the mean SCL was seen between the RY group (105.8 +/- 21.2 mu g/dl) and non-RY group (107.9 +/- 22.7 mu g/dl; p = 0.499). In the RY group, the mean SCL was significantly lower in younger patients, patients with follow-up period <3 years, and male patients. Conclusion: Some patients developed hypocupremia after gastrectomy with RY reconstruction, but the number is acceptably low, and physical symptoms were unusual.

• 出版日期2015