Brain morphometric analysis predicts decline of intelligence quotient in children with sickle cell disease: A preliminary study

作者：Chen Rong^*; Krejza Jaroslaw^*; Arkuszewski Michal; Zimmerman Robert A; Herskovits Edward H; Melhem Elias R

来源：Advances in Medical Sciences, 2017, 62(1): 151-157.

DOI：10.1016/j.advms.2016.09.002

• Sickle cell disease
• Cognitive decline
• Magnetic resonance
• Biomarker
• Predictive modeling

Purpose: For children with sickle cell disease (SCD) and at low risk category of stroke, we aim to build a predictive model to differentiate those with decline of intelligence-quotient (IQ) from counterparts without decline, based on structural magnetic-resonance (MR) imaging volumetric analysis.
Materials and methods: This preliminary prospective cohort study included 25 children with SCD, homozygous for hemoglobin S, with no history of stroke and transcranial Doppler mean velocities below 170 cm/s at baseline. We administered the Kaufman Brief Intelligence Test (K-BIT) to each child at yearly intervals for 2-4 years. Each child underwent MR examination within 30 days of the baseline K-BIT evaluation date. We calculated K-BIT change rates, and used rate of change in K-BIT to classify children into two groups: a decline group and a non-decline group. We then generated predictive models to predict K-BIT decline/non-decline based on regional gray-matter (GM) volumes computed from structural MR images.
Results: We identified six structures (the left median cingulate gyrus, the right middle occipital gyrus, the left inferior occipital gyrus, the right fusiform gyrus, the right middle temporal gyrus, the right inferior temporal gyrus) that, when assessed for volume at baseline, are jointly predictive of whether a child would suffer subsequent K-BIT decline. Based on these six regional GM volumes and the baseline K-BIT, we built a prognostic model using the K* algorithm. The accuracy, sensitivity and specificity were 0.84, 0.78 and 0.86, respectively.
Conclusions: GM volumetric analysis predicts subsequent IQ decline for children with SCD.

• 出版日期2017-3