科研之友
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摘要
The tetrapeptide segment LVFF from the central hydrophobic core of amyloid -peptide, A(17-20), based methacrylate monomer was polymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization to afford well-defined side-chain peptide polymers. The polymer was transformed to carry primary amino groups in the peptide terminals, depicting pH-responsiveness and was further modified to provide amphiphilic graft copolymer-based nanocarriers with pH-triggered dynamic dye release capability. The polymers acquired -helical conformation guided by A(17-20) peptide. Computational studies were performed to investigate the secondary interactions of the peptide-based materials.
- 出版日期2015-10
