Angiographic correlation of myocardial perfusion imaging with half the radiation dose using ordered-subset expectation maximization with resolution recovery software

作者：Gutstein Ariel; Navzorov Roman; Solodky Alejandro; Mats Israel; Kornowski Ran; Zafrir Nili^*

来源：Journal of Nuclear Cardiology, 2013, 20(4): 539-544.

DOI：10.1007/s12350-013-9730-2

• Myocardial perfusion imaging: SPECT
• half radiation dose
• coronary angiography

We previously described the feasibility of performing myocardial perfusion imaging (MPI) with half the technetium (Tc-99m) activity using ordered-subset expectation maximization with resolution recovery (OSEM-RR) processing. This study sought to assess the accuracy of this technique by correlating the findings with coronary angiography.
Of 290 patients who underwent MPI-gated SPECT using a half dose of Tc-99m sestamibi and OSEM-RR software in 2010-2012 at a tertiary medical center, 62 were referred for invasive coronary angiography within 90 days and formed the study group. Ischemia was defined as a summed difference score (SDS) of > 3 on the MPI scan. Luminal stenosis of a parts per thousand yen70% on invasive coronary angiography served as the reference.
Mean Tc-99m activity per study was 23.9 +/- A 11.5 mCi and mean effective radiation dose was 7.2 +/- A 3.4 mSv. MPI revealed no abnormalities in 10 patients (16.2%), myocardial infarction only in 8 patients (12.9%), and ischemia in 44 patients (71.1%). Overall sensitivity, specificity, and positive and negative predictive values for MPI compared to invasive angiography were 89.1%, 75.0%, 91.1%, and 70.5%, respectively.
MPI SPECT performed with a half dose of Tc-99m and OSEM-RR image processing correlates well with invasive angiography.

• 出版日期2013-8