Diterpenoids from Isodon adenantha

作者:Jiang B; Yang H; Li ML; Hou AJ; Han QB; Wang SJ; Li SH; Sun HD*
来源:Journal of Natural Products, 2002, 65(8): 1111-1116.
DOI:10.1021/np020084k

摘要

Eleven new diterpenoids, adenanthins B-L (1-11), together with five known analogues, calcicolin B (12), adenanthin (13), weisiensin A (14), nervosanin (15), and forrestin C (16), were isolated from the aerial parts of Isodon adenantha The structures of 1-11 were elucidated on the basis of spectral methods, as well as the X ray crystallographic analysis of 11 Compounds 2, 5, and 14 showed significant inhibitory activities against K562 cells, with IC50 values less than 4 mug/mL, respectively.