Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.

作者：Nakashima Ken ichi; Tomida Junko; Kamiya Tetsuro; Hirai Takao; Morita Yuji; Hara Hirokazu; Kawamura Yoshiaki; Adachi Tetsuo; Inoue Makoto

来源：Tetrahedron Letters, 2018, 59(13): 1212-1215.

DOI：10.1016/j.tetlet.2018.02.032

• Endophytic fungus
• Diaporthe
• Diphenyl ether
• Depsidone

Diaporthols A (1) and B (2), two diphenyl ether derivatives, were isolated from cultures of an endophytic fungus Diaporthe sp. ECN-137 obtained from the leaves of Phellodendron amurense. The structures of 1 and 2 were determined by extensive spectroscopic analyses, and the structure of 2 was confirmed by X-ray crystallographic analysis. Compounds 1 and 2 showed anti-migration activities in TGF-beta 1-elicited MDA-MB-231 breast cancer cells at a concentration of 20 mu M.

• 出版日期2018-3-28