An immunoglobulin G4-related disease mimicking postoperative lung cancer recurrence

作者：Nakazawa Seshiru; Shimizu Kimihiro^*; Nakano Tetsuhiro; Kakegawa Seiichi; Atsumi Jun; Kamiyoshihara Mitsuhiro; Hirato Junko; Takeyoshi Izumi

来源：Modern Rheumatology, 2012, 22(5): 787-790.

DOI：10.1007/s10165-011-0580-y

• Immunoglobulin G4-related disease
• Lung cancer recurrence
• Mikulicz%26apos
• s disease
• Non-small-cell lung cancer
• Positron emission tomography and computed tomography

A postoperative lung cancer patient presented with lymphadenopathy, pleural thickening, and 18F-fluorodeoxyglucose (FDG) uptake on a positron emission tomography-computed tomography (PET-CT) scan. Lung cancer recurrence was initially suspected, but bilateral submandibular masses with 18F-FDG uptake indicated the possibility of a systemic disease, such as Mikulicz%26apos;s disease. High serum immunoglobulin G4 (IgG4) and IgG4-positive plasma cell infiltration in the submandibular glands led to the diagnosis of IgG4-related disease. After systemic steroid therapy, 18F-FDG uptake decreased in both the submandibular glands and the suspected recurrent lesions.

• 出版日期2012-9