Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

作者：Gonzalez Hugo; Elgueta Daniela; Montoya Andro; Pacheco Rodrigo^*

来源：Journal of Neuroimmunology, 2014, 274(1-2): 1-13.

DOI：10.1016/j.jneuroim.2014.07.012

• Neuroinflammation
• Neurodegenerative disorders
• Microglia
• T-cells
• Neo-antigens
• Blood-brain barrier

Neuroinflammation constitutes a fundamental process involved in the progression of several neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and multiple sclerosis. Microglial cells play a central role in neuroinflammation, promoting neuroprotective or neurotoxic microenvironments, thus controlling neuronal fate. Acquisition of different microglial functions is regulated by intercellular interactions with neurons, astrocytes, the blood-brain barrier, and T-cells infiltrating the central nervous system. In this study, an overview of the regulation of microglial function mediated by different intercellular communications is summarised and discussed. Afterward, we focus in T-cell-mediated regulation of neuroinflammation involved in neurodegenerative disorders.

• 出版日期2014-9-15