Antibiotic susceptibility in prostate-derived Propionibacterium acnes isolates

作者：Olsson Jan^*; Davidsson Sabina; Unemo Magnus; Molling Paula; Andersson Swen Olov; Andren Ove; Soderquist Bo; Sellin Mats; Elgh Fredrik

来源：Acta Pathologica, Microbiologica et Immunologica Scandinavica, 2012, 120(10): 778-785.

DOI：10.1111/j.1600-0463.2012.02905.x

• Propionibacterium
• prostate
• antibiotic
• prostatitis
• cancer

The aim of this study was to determine antibiotic susceptibility of Propionibacterium acnes isolates from prostate. Prostate-derived P. acnes isolates (n = 24, Umea %26 Orebro, Sweden, 20072010) and a panel of control strains (n = 25, Sweden) collected from skin and deep infections were assessed for resistance to penicillin G, piperacillintazobactam, imipenem, gentamicin, azithromycin, erythromycin, vancomycin, ciprofloxacin, moxifloxacin, tetracycline, tigecycline, fusidic acid, clindamycin, rifampicin, linezolid, daptomycin, trimethoprimsulfamethoxazole, and metronidazole. In addition, the isolates were tested for inducible clindamycin resistance. All prostate derived P. acnes isolates displayed wild-type distribution of MIC-values, without evidence of acquired resistance. In the reference panel, 5 of 25 isolates had acquired macrolide resistance with cross-resistance to azithromycin, clindamycin, and erythromycin. In addition, one of these isolates was resistant to tetracycline.

• 出版日期2012-10