A comparative study on the risk of second primary cancers in out-of-field organs associated with radiotherapy of localized prostate carcinoma using Monte Carlo-based accelerator and patient models

作者：Bednarz Bryan^*; Athar Basit; Xu X George

来源：Medical Physics, 2010, 37(5): 1987-1994.

DOI：10.1118/1.3367012

• biomedical equipment
• cancer
• dosimetry
• linear accelerators
• Monte Carlo methods
• phantoms
• radiation therapy
• risk management

Methods: Monte Carlo simulations were performed using a detailed medical linear accelerator model and an anatomically realistic adult male whole-body phantom. A four-field box treatment, a four-field box treatment plus a six-field boost, and a seven-field IMRT treatment were simulated. Using BEIR VII risk models, the age-dependent lifetime attributable risks to various organs outside the primary beam with a known predilection for cancer were calculated using organ-averaged equivalent doses.
Results: The four-field box treatment had the lowest treatment-related second primary cancer risks to organs outside the primary beam ranging from 7.3x10(-9) to 2.54x10(-5)%/MU depending on the patients age at exposure and second primary cancer site. The risks to organs outside the primary beam from the four-field box and six-field boost and the seven-field IMRT were nearly equivalent. The risks from the four-field box and six-field boost ranged from 1.39x10(-8) to 1.80x10(-5)%/MU, and from the seven-field IMRT ranged from 1.60x10(-9) to 1.35x10(-5)%/MU. The second cancer risks in all organs considered from each plan were below the baseline risks.
Conclusions: The treatment-related second cancer risks in organs outside the primary beam due to 3D-CRT and IMRT is small. New risk assessment techniques need to be investigated to address the concern of radiation-induced second cancers from prostate treatments, particularly focusing on risks to organs inside the primary beam.

• 出版日期2010-5