A Retrospective Analysis of Pregnancy Outcomes after Kidney Transplantation in a Single Center

作者：Akar Munire Erman^*; Ozekinci Murat; Sanhal Cem; Kececioglu Nilgun; Mendilcioglu Inanc; Senol Yesim; Dirican Kerem; Kocak Huseyin; Dinckan Ayhan; Suleymanlar Gultekin

来源：Gynecologic and Obstetric Investigation, 2015, 79(1): 13-18.

DOI：10.1159/000365815

• Renal transplant recipient
• Immunosuppression
• Pregnancy

Background: We reported pregnancy outcomes after kidney transplantation in a single transplant center. Methods: We reviewed the perinatal outcomes of female kidney transplant patients of reproductive age (18-40 years) from 1987 to 2011. Results: A total of 246 patients were reviewed. Of these, 43 women registered a pregnancy following kidney transplantation. The mean patient age was 31.3 +/- 4.2 years (range 24-40). The mean transplant-conception interval was 35.9 +/- 12.6 months (range 24-120); 9 patients had a cadaveric allograft. The human leukocyte antigen match was >= 3/6 for 34 patients. The rate of live births was 29/43 (67.4%), miscarriage 10/43 (23.2%), preterm delivery 7/29 (24.1%), preeclampsia 5/29 (17.2%), and intrauterine growth retardation 2/29 (6.9%). Overall, 3/29 patients (10.3%) received a blood transfusion during pregnancy due to persistent symptomatic anemia, despite iron replacement and erythropoietin therapy; 24 patients (82%) had a cesarean section delivery; 3 patients had kidney rejection during pregnancy, with 2 occurring during the 6th postpartum month. Conclusion: Pregnancy should be considered a high risk in renal transplant recipients, necessitating close follow-up.

• 出版日期2015