A mitochondria-targeted near-infrared fluorescent probe with a large Stokes shift for real-time detection of hypochlorous acid

作者：Jiao, Xiaojie; Huang, Kun; He, Song; Liu, Chang^*; Zhao, Liancheng; Zeng, Xianshun^*

来源：Organic and Biomolecular Chemistry, 2019, 17(1): 108-114.

DOI：10.1039/c8ob02583e

• ELECTRON-TRANSFER
• SELECTIVE DETECTION
• OXIDATIVE STRESS
• RECENT PROGRESS
• HOCL
• WATER
• DESIGN
• MYELOPEROXIDASE
• CHEMOSENSOR
• STRATEGY

Hypochlorous acid (HOCl) has been known to be intertwined with various pathophysiological processes. In this paper, a novel mitochondria-targeted near-infrared (NIR) fluorescent probe L based on a chromenylium-phenothiazine conjugate has been designed and synthesized for the detection of hypochlorous acid. Due to the HOCl-promoted intramolecular charge transfer processes, the probe L shows near-infrared fluorescence emission at 672 nm, large Stokes shifts of 97 nm, fast response, and high selectivity and sensitivity. Furthermore, the probe L is biocompatible, cell-membrane permeable and mitochondria-targetable, and can be used for endogenous HOCl imaging in living cells.

• 出版日期2019-1-7
• 单位哈尔滨工业大学; 天津理工大学; 西华师范大学