AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians

作者：Nygaard Marianne^*; Soerensen Mette; Flach**art Friederike; Mengel From Jonas; Tan Qihua; Schreiber Stefan; Nebel Almut; Christensen Kaare; Christiansen Lene

来源：European Journal of Human Genetics, 2013, 21(5): 574-577.

DOI：10.1038/ejhg.2012.196

• human longevity
• AKT1
• association

In addition to APOE and FOXO3, AKT1 has recently been suggested as a third consistent longevity gene, with variants in AKT1 found to be associated with human lifespan in two previous studies. Here, we evaluated AKT1 as a longevity-associated gene across populations by attempting to replicate the previously identified variant rs3803304 as well as by analyzing six additional AKT1 single-nucleotide polymorphisms, thus capturing more of the common variation in the gene. The study population was 2996 long-lived individuals (nonagenarians and centenarians) and 1840 younger controls of Danish and German ancestry. None of the seven SNPs tested were significantly associated with longevity in either a case-control or a longitudinal setting, although a supportive nominal indication of a disadvantageous effect of rs3803304 was found in a restricted group of Danish centenarian men. Overall, our results do not support AKT1 as a universal longevity-associated gene. European Journal of Human Genetics (2013) 21, 574-577; doi:10.1038/ejhg.2012.196; published online 29 August 2012

• 出版日期2013-5