Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes

作者：Dosekova Erika; Filip Jaroslav; Bertok Tomas; Both Peter; Kasak Peter; Tkac Jan

来源：Medicinal Research Reviews, 2017, 37(3): 514-626.

DOI：10.1002/med.21420

• nanotechnology
• nanomaterials
• glycomics
• glycan sensing
• glycan enrichment and active glycoprofiling
• glycan-based vaccines/therapeutics
• cell tissue targeting/imaging and drug delivery

This review comprehensively covers the most recent achievements (from 2013) in the successful integration of nanomaterials in the field of glycomics. The first part of the paper addresses the beneficial properties of nanomaterials for the construction of biosensors, bioanalytical devices, and protocols for the detection of various analytes, including viruses and whole cells, together with their key characteristics. The second part of the review focuses on the application of nanomaterials integrated with glycans for various biomedical applications, that is, vaccines against viral and bacterial infections and cancer cells, as therapeutic agents, for in vivo imaging and nuclear magnetic resonance imaging, and for selective drug delivery. The final part of the review describes various ways in which glycan enrichment can be effectively done using nanomaterials, molecularly imprinted polymers with polymer thickness controlled at the nanoscale, with a subsequent analysis of glycans by mass spectrometry. A short section describing an active glycoprofiling by microengines (microrockets) is covered as well.

• 出版日期2017-5