An NHC-Catalyzed Cross-Benzoin-Esterification Sequential Reaction for the Synthesis of Trifluoromethyl-Substituted α,β-Unsaturated Esters

作者：Zhao, Qian; Feng, Li-Ying; Huang, Wei; He, Xiang-Hong; Peng, Cheng^*; Han, Bo^*

来源：Synlett, 2016, 27(13): 2034-2038.

DOI：10.1055/s-0035-1561631

• organocatalytic reaction
• multicomponent reaction
• NHC catalysis
• trifluoromethylated compounds
• cross-benzoin
• esterification

Efficient preparation of synthetically important CF3-containing ,-unsaturated esters is described using an NHC-catalyzed multicomponent reaction. This approach combines sequential NHC-mediated HOMO and LUMO activation to produce a C-C bond and C-O bond in a one-pot operation.

• 出版日期2016-8
• 单位成都中医药大学; 中国人民解放军陆军总医院