Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?

作者：Sitek Emilia J^*; Narozanska Ewa; Barczak Anna; Jasinska Myga Barbara; Harciarek Michal; Chodakowska Zebrowska Malgorzata; Kubiak Malgorzata; Wieczorek Dariusz; Konieczna Seweryna; Rademakers Rosa; Baker Matt; Berdynski Mariusz; Brockhuis Bogna; Barcikowska Maria; Zekanowski Cezary; Heilman Kenneth M; Wszolek Zbigniew K; Slawek Jaroslaw

来源：Neurocase, 2014, 20(1): 69-86.

DOI：10.1080/13554794.2012.732087

• Frontotemporal dementia
• Writing
• Neuropsychological assessment
• Dysexecutive agraphia
• Spatial agraphia
• Aphasic agraphia

Objectives: Patients with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) may be agraphic. The study aimed at characterizing agraphia in individuals with a P301L MAPT mutation.Methods: Two pairs of siblings with FTDP-17 were longitudinally examined for agraphia in relation to language and cognitive deficits.Results: All patients presented with dysexecutive agraphia. In addition, in the first pair of siblings one sibling demonstrated spatial agraphia with less pronounced allographic agraphia and the other sibling had aphasic agraphia. Aphasic agraphia was also present in one sibling from the second pair.Conclusion: Agraphia associated with FTDP-17 is very heterogeneous.

• 出版日期2014-1-2