Non-motor disorders in Parkinson's disease

作者：Merello M^*

来源：Revista de Neurologia, 2008, 47(5): 261-270.

• autonomic
• cognitive
• levodopa
• non-motor symptoms
• Parkinsonism
• Parkinson's diease

Introduction. Parkinson's disease (PD) is a progressive disorder that is strongly linked to non-motor symptoms (NMS). Unfortunately, these symptoms have been almost neglected for many years and only recently have reseachers begun to assess how they affect the quality of life in patients with PD. Aims. To review our current understanding of the subject and to highlight the importance of NMS in PD. Development. Recent studies have emphasised the fact that the basal ganglia play an important role in a number of non-motor functions. At the same time, the exclusive involvement of the substantia nigra in PD is being reviewed and the developement of PD has been defined as a continuum that covers a range of different stages, including non-dopaminergic systems and nuclei. This would account for the constellation of non-motor symptoms that do not respond to dopamine replacement therapy and which affect patients with PD, such as depression, apathy, sialorrhea and urinary incontinence, among others. Conclusions. NMS make a significantly contribution to the morbidity and mortality rates of PD and are often the main cause of hospitalisation of patients with PD. Current evidence suggests that some NMS, such as importance of reaching a diagnosis faster and earlier.

• 出版日期2008-9-1