Automated lamina cribrosa microstructural segmentation in optical coherence tomography scans of healthy and glaucomatous eyes

作者：Nadler Zach^*; Wang Bo; Wollstein Gadi; Nevins Jessica E; Ishikawa Hiroshi; Kagemann Larry; Sigal Ian A; Ferguson R Daniel; Hammer Daniel X; Grulkowski Ireneusz; Liu Jonathan J; Kraus Martin F; Lu Chen D; Hornegger Joachim; Fujimoto James G; Schuman Joel S

来源：Biomedical Optics Express, 2013, 4(11): 2596-2608.

DOI：10.1364/BOE.4.002596

We demonstrate an automated segmentation method for in-vivo 3D optical coherence tomography (OCT) imaging of the lamina cribrosa (LC). Manual segmentations of coronal slices of the LC were used as a gold standard in parameter selection and evaluation of the automated technique. The method was validated using two prototype OCT devices; each had a subject cohort including both healthy and glaucomatous eyes. Automated segmentation of in-vivo 3D LC OCT microstructure performed comparably to manual segmentation and is useful for investigative research and in clinical quantification of the LC.

• 出版日期2013-11-1
• 单位MIT