Determinants of DHA levels in early infancy: Differential effects of breast milk and direct fish oil supplementation

作者：Meldrum S J^*; D' Vaz N; Casadio Y; Dunstan J A; Krogsgaard Larsen N Niels; Simmer K; Prescott S L

来源：Prostaglandins, Leukotrienes and Essential Fatty Acids, 2012, 86(6): 233-239.

DOI：10.1016/j.plefa.2012.03.006

• Docosahexaenoic acid
• Infancy
• Breast milk
• Fish oil

Introduction: Although omega (n)-3 long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), intakes are important during infancy, the optimal method of increasing infant status remains unclear. We hypothesized that high-dose infant fish oil supplementation would have greater relative effects upon n-3 LCPUFA status at six months of age than breast milk fatty acids. %26lt;br%26gt;Patients and methods: Infants (n=420) were supplemented daily from birth to six months with fish oil or placebo. In a subset of infants, LCPUFA levels were measured in cord blood, breast milk and in infant blood at 6 months. %26lt;br%26gt;Results: DHA levels increased in the fish oil group relative to placebo (p %26lt; 05). Breast milk DHA was the strongest predictor of infant erythrocyte DHA levels (p= %26lt; 001). This remained significant after adjustment for cord blood DHA, supplementation group and adherence. %26lt;br%26gt;Conclusion: In this cohort, breast milk DHA was a greater determinant of infant erythrocyte n-3 LCPUFA status, than direct supplementation with fish oil.

• 出版日期2012-6