Antimicrobial and Physicochemical Characterizations of Thiosemicarbazide and S-Triazole Derivatives

作者：Kusmierz Edyta; Siwek Agata; Kosikowska Urszula; Malm Anna; Plech Tomasz; Wrobel Andrzej; Wujec Monika^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2014, 189(10): 1539-1545.

DOI：10.1080/10426507.2014.902831

• structure-activity relationship (SAR)
• s-triazole
• Antibacterial activity
• thiosemicarbazide derivatives
• physicochemical properties

Two series of thiosemicarbazide derivatives and three series of s-triazole derivatives have been synthesized. All of these compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative bacterial strains. Among tested thiosemicarbazide derivatives, the best bioactivity was detected for two 1-formylthiosemicarbazides with 3-/4-tolyl substitution (1 l, 1 m) (MICs range between 31.25 and 250 mu g/mL). All tested s-triazole derivatives exhibited lower antibacterial activity than their acyclic precursors.

• 出版日期2014-10-3