A stretchable and screen-printed electrochemical sensor for glucose determination in human perspiration

作者：Abellan-Llobregat, A.^*; Jeerapan, Itthipon; Bandodkar, A.; Vidal, L.; C****s, A.; Wang, J.; Morallon, E.

来源：Biosensors and Bioelectronics, 2017, 91: 885-891.

DOI：10.1016/j.bios.2017.01.058

• Glucose biosensor
• Printed electronics
• Stretchable device
• H2O2
• Catalyst
• Perspiration

Here we present two types of all-printable, highly stretchable, and inexpensive devices based on platinum (Pt)-decorated graphite for glucose determination in physiological fluids. Said devices are: a non-enzymatic sensor and an enzymatic biosensor, the latter showing promising results. Glucose has been quantified by measuring hydrogen peroxide (H2O2) reduction by chronoamperometry at -0.35 V (vs pseudo-Ag/AgCI) using glucose oxidase immobilized on Pt-decorated graphite. The sensor performs well for the quantification of glucose in phosphate buffer solution (0.25 M PBS, pH 7.0), with a linear range between 0 mM and 0.9 mM, high sensitivity and selectivity, and a low limit of detection (LOD). Thus, it provides an alternative non-invasive and on-body quantification of glucose levels in human perspiration. This biosensor has been successfully applied on real human perspiration samples and results also show a significant correlation between glucose concentration in perspiration and glucose concentration in blood measured by a commercial glucose meter.

• 出版日期2017-5-15