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摘要
alpha-Aminations of ketone-derived nitrones have been developed via [3,3]-rearrangement of the intermediates generated upon condensation with imidoyl chlorides. Careful reagent selection provides synthetically attractive amino protecting groups. The enediamide or alpha'-carbamoyl enamide products can be hydrolyzed to the desired carbonyl, or exposed to electrophiles for further alpha-functionalization.
- 出版日期2012
