An evaluation of the validity and potential utility of facial electromyelogram Responsiveness Index for sedation monitoring in critically ill patients

作者：Walsh Timothy S^*; Everingham Kirsty; Frame Fiona; Lapinlampi T Petteri; Sarkela Mika O K; Uutela Kimmo; Viertio Oja Hanna E

来源：Journal of Critical Care, 2014, 29(5): 886.e1.

DOI：10.1016/j.jcrc.2014.05.008

• Sedation
• Monitoring
• Critical care

Purpose: The purpose of this study is to explore the validity of a novel sedation monitoring technology based on facial electromyelography (EMG) in sedated critically ill patients.
Materials and methods: The Responsiveness Index (RI) integrates the preceding 60 minutes of facial EMG data. An existing data set was used to derive traffic light cut-offs for low (red), intermediate (amber), and higher (green) states of patient arousal. The validity of these was prospectively evaluated in 30 sedated critically ill patients against hourly Richmond Agitation Sedation Scale (RASS) assessments with concealment of RI data from clinical staff.
Results: With derivation data, an RI less than or equal to 35 had best discrimination for a Ramsay score of 5/6 (sensitivity, 90%; specificity, 79%). For traffic lights, we chose RI less than or equal to 20 as red, 20 to 40 as amber, and more than 40 as green. In the prospective study, RI values were red/amber for 76% of RASS -5/-4 assessments, but RI varied dynamically over time in many patients, and discordance with RASS may have resulted from the use of 1 hour of data for RI calculations. We also noted that red/amber values resulted from sleep, encephalopathy, and low levels of stimulation.
Conclusions: Responsiveness Index is not directly comparable with clinical sedation scores but is a potential continuous alert to possible deep sedation in critically ill patients.

• 出版日期2014-10