Mixed-ligand manganese(II)-phenolate complexes: study of DNA cleavage, cytotoxic activity, and induction of apoptosis

作者：Gao, En-Jun^*; Zhang, Ying; Lin, Lin; Wang, Ren-Shu; Dai, Lei; Liang, Qi; Zhu, Ming-Chang; Wang, Mei-Lin; Liu, Lei; He, Wen-Xuan; Zhang, Yan-Jin

来源：Journal of Coordination Chemistry, 2011, 64(22): 3992-4005.

DOI：10.1080/00958972.2011.634910

• Manganese
• Fluorescence
• Cleavage
• Cytotoxicity
• Apoptosis

Two manganese complexes, [Mn(L-1)(2)(dibe)(2)](L-1) (1) and [Mn(L-2)(2)(dibe)(2)] (2) (where L-1 = 2,2'-bipyridine (bipy), L-2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells.

• 出版日期2011
• 单位沈阳化工大学