Mitochondrial Haplogroups Are Associated With Clinical Pattern of AIDS Progression in HIV-Infected Patients

作者：Guzman Fulgencio Maria; Luis Jimenez Jose; Garcia Alvarez Monica; Maria Bellon Jose; Fernandez Rodriguez Amanda; Campos Yolanda; Rodriguez Carmen; Gonzalez Garcia Juan; Riera Melchor; Viciana Pompeyo; Angeles Munoz Fernandez Ma; Resino Salvador^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2013, 63(2): 178-183.

DOI：10.1097/QAI.0b013e3182893f74

• AIDS
• mitochondria
• haplogroups
• mtDNA
• polymorphisms
• LTNPs

We performed a cross-sectional study in 469 HIV-infected patients, whose mitochondrial haplogroups were genotyped to study their association with the clinical pattern of AIDS progression. The chance of not having an AIDS progression was 1.45 [95% of confidence interval (CI) = 1.02 to 2.05, P = 0.035) times greater in patients with cluster HV and 1.51 (95% CI = 1.06 to 2.18, P = 0.021) times greater in patients with haplogroup H. However, we only found significant values for haplogroup H (odds ratio = 1.52, 95% CI = 1.01 to 2.32, P = 0.049) in an ordinal logistic regression adjusted by gender, age at HIV infection, intravenous drug users, and hepatitis C virus infection. These data suggest that mitochondrial haplogroups might play a significant role in AIDS progression.

• 出版日期2013-6-1