科研之友
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摘要
The multicomponent reactions of iodobenzoic acids, aryl boronic acids, and dichloromethane (DCM) have been designed for the synthesis of various methylene-bridged bis-biaryl functionalized carboxylates. Under the catalysis of Pd(OAc)(2), the formation of the products involves the cascade Suzuki coupling and CH2Cl2-base bis-esterification. The present work offers a direct and practical route to the synthesis of novel carboxylate scaffolds with extended diversity.
