Proteins as biomarkers of carbon monoxide neurotoxicity

作者：Gawlikowski Tomasz; Golasik Magdalena; Gomolka Ewa; Piekoszewski Wojciech^*

来源：Inhalation Toxicology, 2014, 26(14): 885-890.

DOI：10.3109/08958378.2014.970786

• CO poisoning
• neurological biomarkers
• serum
• S100B protein
• Tau protein

Context: Carbon monoxide (CO) poisoning is the most common form of accidental lethal poisoning and is associated with a risk of brain damage in survivors. Objective: The goal of this study was to examine whether Tau protein or S100B protein may be used as a biomarker for acute brain dysfunction. %26lt;br%26gt;Materials and methods: The determination of Tau and S100B proteins was performed in serum samples collected from 27 CO-poisoned patients and 12 healthy volunteers. %26lt;br%26gt;Results: The level of Tau protein in the serum of patients (444 +/- 227 ng L-1) differed significantly compared with those in the healthy controls (240 +/- 61 ng L-1) and correlated with the level of carboxyhemoglobin. A higher concentration of Tau protein was found in patients who had lost consciousness during CO exposure. The concentration of S100B in the serum of CO-poisoned subjects (0.08 +/- 0.03 mg L-1) was not statistically different from values obtained for the controls (0.07 +/- 0.02 mg L-1). %26lt;br%26gt;Conclusion: CO poisoning appears to be associated with an elevated level of Tau and S100B proteins in the serum of patients who had suffered a loss of consciousness. The study has shown that Tau protein is a more sensitive biomarker than S100B protein for the earlier stage of neurotoxic effects of CO intoxication.

• 出版日期2014-12