A randomised, double-blind, placebo-controlled parallel trial of closed-loop infraslow brain training in food addiction

作者：Leong Sook Ling^*; Vanneste Sven; Lim Joyce; Smith Mark; Manning Patrick; De Ridder Dirk^*

来源：Scientific Reports, 2018, 8(1): 11659.

DOI：10.1038/s41598-018-30181-7

The posterior cingulate cortex (PCC) is involved in food craving in obese food addicted individuals. This randomised, double-blind, placebo-controlled parallel study explored the potential therapeutic effects of infraslow neurofeedback (ISF-NF) on food craving targeting the PCC in obese women with symptoms of food addiction. Participants received six sessions of either ISF-NF (n = 11) or placebo (n = 10) over a three-week period. There were no reported adverse effects. Electrophysiologically, there were significant increases in infraslow activity (p = 0.0002) and infraslow/beta nesting (p < 0.001) in the PCC in the ISF-NF group (mean r = 0.004 +/- 0.002) compared to placebo (mean r = 0.02 +/- 0.002) two days after the last intervention. Also, there was a significant decrease in different dimensions of state food craving compared to baseline and to placebo. Findings suggest that source localized IFS-NF results in electrophysiological changes and may be associated with reduced food craving. This trial is registered at www.anzctr.org.au, identifier, ACTRN12617000601336. This study was funded by the Otago Medical Research Grant: CT375.

• 出版日期2018-8-3