Alcohol attenuates myocardial ischemic injury

作者：Scrimgeour Laura A; Potz Brittany A; Elmadhun Nassrene Y; Chu Louis M; Sellke Frank W

来源：Surgery, 2017, 162(3): 680-687.

DOI：10.1016/j.surg.2017.04.014

Background. Moderate alcohol consumption is cardioprotective but the mechanism of action remains unclear. Nuclear factor kappa-B regulates the expression of genes involved in inflammation, stress, and apoptosis. We used a swine model of diet-induced metabolic syndrome to investigate the effects of red wine and vodka on nuclear factor kappa-B signaling and cytokine activity in chronically ischemic myocardium.
Methods. Yorkshire swine were given a high-fat diet for 4 weeks; an ameroid constrictor was then placed on the left circumflex artery. The high-fat diet was continued and the swine were divided into 3 groups for 7 weeks: hypercholesterolemic diet alone (control, n = 8), hypercholesterolemic diet with vodka (vodka, n = 8), and hypercholesterolemic diet with wine (wine, n = 8). Ischemic myocardium was analyzed by Western blot and cytokine array.
Results. Administration of alcohol was associated with decreased expression of inhibitor of kappa-B kinase complex a, inhibitor of kappa-B kinase complex beta, and phosphorylated inhibitor of kappa-B beta in the ischemic myocardium compared with the control group. Alcohol administration demonstrated an increase in nuclear factor K-B in the ischemic myocardium. Both wine and vodka demonstrated a significant decrease in leptin, interleukin-1 alpha, IL-13, IL-15, and interferon-gamma. Vodka demonstrated a significant decrease in phosphorylated BCL-2 and caspase-9.
Conclusion. In ischemic myocardium, alcohol modulates the nuclear factor kappa-B pathway, which may contribute to the adaptive response of tissues to the stress of ischemia. Furthermore, both wine and vodka decreased multiple proinflammatory cytokines. This study provides a mechanism by which alcohol may be cardioprotective in ischemic myocardium.

• 出版日期2017-9