APIUM GRAVEOLENS EXTRACT ATTENUATES ADJUVANT INDUCED ARTHRITIS BY REDUCING OXIDATIVE STRESS

作者：Choosri Nutjanat; Tanasawet Supita; Chonpathompikunlert Pennapa; Sukketsiri Wanida^*

来源：Journal of Food Biochemistry, 2017, 41(1): UNSP e12276.

DOI：10.1111/jfbc.12276

The purpose of this study was to investigate the effects of an Apium graveolens extract (AGE) on the arthritis in rats induced using Complete Freund's adjuvant (CFA). Arthritis was induced by injecting CFA into the subplantar of the left hind paws. The AGE (250, 500, 1000 mg/kg) and prednisone 10 mg/kg were given orally at day 5 to day 28 after induction. Treatment of AGE significantly attenuated the severity of CFA-induced arthritis and decreased the arthritis score, paw and ankle thickness. Any histopathological changes were noted. The plasma levels of total peroxide (TP) and oxidative stress index (OSI) were significantly decreased by oral administration of AGE as well as the total antioxidant status (TAS) was significantly increased. Furthermore, oral administrations of AGE remarkably attenuated the increased nitric oxide (NO) levels after induction as was also the myeloperoxidase (MPO) activity in plasma of CFA-induced arthritic rats.

• 出版日期2017-2