An efficient, eco-friendly and sustainable tandem oxidative amidation of alcohols with amines catalyzed by heteropolyanion-based ionic liquids via a bifunctional catalysis process

作者：Fu, Renzhong; Yang, Yang^*; Feng, Wei; Ge, Qiuxia; Feng, Yan; Zeng, Xiaojun; Chai, Wen; Yi, Jun^*; Yuan, Rongxin

来源：Tetrahedron, 2016, 72(50): 8319-8326.

DOI：10.1016/j.tet.2016.11.002

• Amide
• Ionic liquid
• Microwave-assisted
• Oxidative amidation
• Solvent-free condition

An efficient, eco-friendly and sustainable method for the tandem oxidative amidation of alcohols with amines has been reported. Using heteropolyanion-based ionic liquids as the catalyst and tert-butyl hydroperoxide as the oxidant, this amidation reaction is operationally straightforward and provides a series of primary, secondary and tertiary amides derivatives in moderate to good yields. Solvent-free media, microwave-promoted conditions and reusability of catalysts are the main highlights. Further, the proposed bifunctional catalysis mechanistic pathway has been briefly investigated in this report.

• 出版日期2016-12-15
• 单位常熟理工学院