Differential Loss of Invariant Natural Killer T Cells and FoxP3(+) Regulatory T Cells in HIV-1 Subtype A and Subtype D Infections

作者：Flach Britta; Naluyima Prossy; Blom Kim; Gonzalez Veronica D; Eller Leigh Anne; Laeyendecker Oliver; Quinn Thomas C; Serwadda David; Sewankambo Nelson K; Wawer Maria J; Gray Ronald H; Michael Nelson L; Wabwire Mangen Fred; Robb Merlin L; Eller Michael A; Sandberg Johan K^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2013, 63(3): 289-293.

DOI：10.1097/QAI.0b013e31828b2073

• HIV-1
• viral subtype
• AIDS
• iNKT cell
• CD1d
• T regulatory cell

HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3(+) regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

• 出版日期2013-7-1