Direct synthesis of polysubstituted 2-aminothiophenes by Cu(II)-catalyzed addition/oxidative cyclization of alkynoates with thioamides

作者：Ge, Li-Shi; Wang, Zheng-Lin; An, Xing-Lan; Luo, Xiaoyan^*; Deng, Wei-Ping

来源：Organic and Biomolecular Chemistry, 2014, 12(42): 8473-8479.

DOI：10.1039/c4ob01534g

• ONE-POT SYNTHESIS
• HIGHLY SUBSTITUTED THIOPHENES
• CATALYZED AMINATION
• EFFICIENT SYNTHESIS
• COPPER(I)-CATALYZED SYNTHESIS
• PHARMACOLOGICAL EVALUATION
• 1,3-DICARBONYL COMPOUNDS
• ANTIINFLAMMATORY AGENTS
• BETA-KETOTHIOAMIDES
• S-ALKENYLATION

A facile and direct synthetic method was developed for the construction of structurally important 2-aminothiophenes in moderate to excellent yields (up to 91%), via Cu(II)-catalyzed addition/oxidative cyclization of readily available thioamides with alkynoates under an air atmosphere.

• 出版日期2014-11-14
• 单位华东理工大学