Comparison of performance status with peak oxygen consumption in operable patients with non-small-cell lung cancer

作者：Roman Michael A; Koelwyn Graeme J; Eves Neil D; Horn**y Whitney E; Watson Dorothy; Herndon James E II; Kohman Leslie; Loewen Gregory; Jones Lee W^*

来源：Respirology, 2014, 19(1): 105-108.

DOI：10.1111/resp.12162

• exercise
• exercise test
• non-small-cell lung cancer
• performance status
• physiology

Background and objectiveIn this era of increasing options for treatment of surgical' lung cancer patients, preoperative physiologic assessment of accurate patient selection is becoming more important. The variability in an objective measure of cardiorespiratory fitness (peak oxygen consumption (VO2peak)) across performance in operable non-small-cell lung cancer (NSCLC) patients enrolled in the Cancer and Leukemia Group B trial was compared.
MethodsUsing a cross-sectional design, 392 NSCLC patients underwent an incremental cardiopulmonary cycling exercise test to symptom limitation with expired gas analysis to determine VO2peak. Performance status (PS) was assessed using the Eastern Cooperative Oncology Group (ECOG) tool.
ResultsThere was a significant decrease in VO2peak across increasing ECOG categories (P<0.0001). However, there was a large range in VO2peak for any given ECOG category with overlap between categories (ECOG 0: 5.0-31.5mL/kg/min; ECOG 1: 4.3-24.8mL/kg/min; ECOG 2: 8.9-21.9mL/kg/min; ECOG 3; 3.3-11.7mL/kg/min).
ConclusionsPS scoring systems do not provide a sensitive measure of functional status. Objective measures such as VO2peak may be a useful in the clinical management of oncology patients.
We provide preliminary evidence illustrating considerable variability in an objective measure of physical performance status (VO2peak) in comparison with a clinically established subjective measure (ECOG performance status).

• 出版日期2014-1