APOE Genotype and Entorhinal Cortex Volume in Non-Demented Community-Dwelling Adults in Midlife and Early Old Age

作者：Bunce David^*; Anstey Kaarin J; Cherbuin Nicolas; Gautam Prapti; Sachdev Perminder; Easteal Simon

来源：Journal of Alzheimer's Disease, 2012, 30(4): 935-942.

DOI：10.3233/JAD-2012-112126

• Age
• Alzheimer%26apos
• s disease
• APOE
• entorhinal cortex

The apolipoprotein E (APOE) epsilon 4 allele is a risk factor for the neuropathological decline accompanying Alzheimer%26apos;s disease (AD) while, conversely, the epsilon 2 allele offers protection. One of the brain structures exhibiting the earliest changes associated with the disease is the entorhinal cortex. We therefore investigated the volumes of the entorhinal cortex and other structures in the medial temporal lobe including the parahippocampal gyrus, temporal pole, and inferior, middle, and superior temporal cortices, in relation to APOE genotype. Our main objectives were to determine if (a) volumes systematically varied according to allele in a stepwise fashion, epsilon 2%26gt;epsilon 3%26gt;epsilon 4, and (b) associations varied according to age. We investigate this association in 627 non-demented community-dwelling adults in middle age (44 to 48 years; n=314) and older age (64 to 68 years; n=313) who underwent structural MRI scans. We found no evidence of APOE-related variation in brain volumes in the age groups examined. We conclude that if a epsilon 2%26gt;epsilon 3%26gt;epsilon 4 pattern in brain volumes does emerge in non-demented adults living in the community in old age, it is not until after the age of 68 years.

• 出版日期2012