A Longitudinal Twin and Sibling Study of Associations between Insomnia and Depression Symptoms in Young Adults

作者：Gregory Alice M; Rijsdijk Fruhling V; Eley Thalia C; Buysse Daniel J; Schneider Melanie N; Parsons Mike; Barclay Nicola L^*

来源：SLEEP, 2016, 39(11): 1985-1992.

DOI：10.5665/sleep.6228

• insomnia
• depression
• genetics
• twins
• longitudinal

Study Objectives: To estimate genetic and environmental influences on the associations between insomnia and depression symptoms concurrently and longitudinally.
Methods: Behavioral genetic analyses were conducted on data from the British longitudinal G1219 twin/sibling study. One thousand five hundred fifty-six twins and siblings participated at Time 1 (mean age = 20.3 years, SD = 1.76). Eight hundred sixty-two participated at Time 2 (mean age = 25.2 years, SD = 1.73 years). Participants completed the Insomnia Symptoms Questionnaire and the Short Mood and Feelings Questionnaire to assess symptoms of insomnia and depression respectively.
Results: Genetic effects accounted for 33% to 41% of the variance of the phenotypes. The phenotypic correlations were moderate (r = 0.34 to r = 0.52). The genetic correlations between the variables were high (0.73-1.00). Genetic effects accounted for a substantial proportion of the associations between variables (50% to 90%). Non-shared environmental effects explained the rest of the variance and covariance of the traits.
Conclusions: While genetic effects play a modest role in insomnia and depression symptoms separately, they appear to play a more central role in concurrent and longitudinal associations between these phenotypes. This should be acknowledged in theories explaining these common associations.

• 出版日期2016-11-1