Activating muscle stem cells: therapeutic potential in muscle diseases

作者：Boldrin Luisa; Morgan Jennifer E^*

来源：Current Opinion in Neurology, 2007, 20(5): 577-582.

• muscle regeneration
• myogenic stem cells
• satellite cell

Purpose of review
The satellite cell is the principal muscle stem cell. Recent research, however, has highlighted new stem cell sources that, once activated in the muscle tissue, can participate in muscle regeneration. This article reviews the state of research on stem cell populations that have potential for treatment of muscular dystrophies.
Recent findings
Despite recent findings about the stem cell character of satellite cells and their in-vivo myogenic potential, limitations related to muscle precursor cell transfer therapy have encouraged the investigation of stem cell sources other than satellite cells. Current research is focused on identifying the best stem cell in the endothelial compartment, which is able to be systemically delivered to reach all the muscles and to contribute to widespread muscle regeneration within these muscles.
Summary
Current results highlight many possible stem cell sources for stem cell therapy of muscle diseases, and work is ongoing to identify the most effective candidate that is able to robustly regenerate muscle tissue and to functionally repopulate the muscle stem cell compartment.

• 出版日期2007-10