A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo

作者：Shirinian Margret; Kambris Zakaria; Hamadeh Lama; Grabbe Caroline; Journo Chloe; Mahieux Renaud; Bazarbachi Ali^*

来源：Journal of Virology, 2015, 89(15): 8092-8095.

DOI：10.1128/JVI.00918-15

Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-kappa B. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKK gamma/NEMO), thus validating this new in vivo model.

• 出版日期2015-8