An improved synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine

作者：Zhang, Yu-Liu; Xu, Cheng-Tao; Liu, Ting; Zhu, Yong; Luo, Yu^*

来源：Chemistry of Heterocyclic Compounds, 2018, 54(6): 638-642.

DOI：10.1007/s10593-018-2320-0

• pyrimidine
• Janus kinase inhibitor
• ozonolysis
• synthesis

An improved seven-step synthesis of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine from dimethyl malonate with 31% overall yield is described. The procedure is operationally simple and practical for the synthesis of the 4-chloro-7H-pyrrolo[2,3-d]pyrimidine building block.

• 出版日期2018-6
• 单位华东师范大学